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Oral Insulin for Prevention of Diabetes in Relatives
at Risk for Type 1 Diabetes Mellitus

Type 1 diabetes is an autoimmune disease. The immune system makes proteins that attack and destroy the cells in the body that produce insulin. These proteins, called autoantibodies, can be found in the blood up to 10 years before someone is diagnosed with diabetes.

A major goal of TrialNet studies is to delay or prevent diabetes in people with these antibodies.

New: Oral Insulin participant brochure



Can type 1 diabetes be prevented?

If someone in your family has type 1 diabetes, you and other family members may be at risk. TrialNet is working to delay or prevent diabetes in people at risk for developing type 1 diabetes.

How can I find out if I am at risk for type 1 diabetes?

[ ] Are you 1 to 45 years old AND do you have a parent, child, brother, or sister with type 1 diabetes?

OR

[ ] Are you 1 to 20 years old AND do you have a niece, nephew, aunt, uncle, grandparent, half-sibling or cousin with type 1 diabetes?

If so, you can have blood tests as part of the TrialNet Natural History Study. Complete the online screening, call toll free anytime 1 - 800 - HALT - DM1 (1-800-425-8361) or contact a participating center.

If you do not live near a TrialNet center, call us. We can arrange for you to have your blood test at your doctors office or at a local lab. There is no cost to you.

You will learn the results of your first blood test in 4-6 weeks.

If your blood test shows that you have the antibodies, we will invite you to have further blood tests at a study center. These will tell us if you can join a prevention study.

What prevention studies are available?

TrialNet is now testing oral insulin (insulin taken by mouth, not by injection). We will see if oral insulin helps to delay or prevent type 1 diabetes. Results from a recently completed study (called DPT-1) suggest that oral insulin might delay or prevent type 1 diabetes in some people found to be at risk.

If you have antibodies but cannot or do not want to be in the Oral Insulin Study, you can be in the TrialNet Natural History Study. We will monitor you closely for diabetes. In addition, there may be other TrialNet studies that you can join in the future.

If I get into the Oral Insulin Study, what will I be asked to do?

You will take one study capsule each day.

You will come to a study center for blood tests every 6 months, and at other times as needed.

What is TrialNet?

Type 1 Diabetes TrialNet is an international network of researchers dedicated to the study, prevention, and early treatment of type 1 diabetes. (more information)

TrialNet conducts studies to:

For more information on TrialNet studies, call us today at

- In North America, call 1-800-425-8361.
- In the United Kingdom, call 0117 959 6188.
- In Australia and New Zealand, call 03 9345 2562.
- In Italy and Germany, call 39-02-2643 2818.
- In Finland, call 358-2-313 0000.

TrialNet is supported by the United States National Institutes of Health and Department of Health & Human Services, Juvenile Diabetes Research Foundation International, and the American Diabetes Association.

What clinical sites are recruiting for this study?

If you wish to see if you might be eligible for this study and/or for more information, please contact one of the participating sites listed.

The blood test to determine whether or not you are at risk for Type 1 Diabetes is part of the Natural History study. Please see the list of Clinical Centers for more information.

 

Last updated: February 22, 2008